Objectives: As COVID-19 drags on, university students experience more stress and feel more anxious about their studies and career plans. Against the backdrop, this study aims to analyze the moderating effect of family health on the relationship between the spread of COVID-19 and the quality of life in university students. Methods: In order to achieve the purpose of this study, the results of an online survey performed with 216 university students in cities K and D were analyzed using frequency analysis, factor analysis, correlation analysis, regression analysis, and moderating effect analysis. Results: It was found that COVID-19 stress had a significant negative effect on the quality of life in university students, while family health showed a significant positive effect. In addition, the moderating effect of family health was statistically significant on the relationship between COVID-19 stress and the quality of life in university students. Conclusions: This study found that family health plays an essential role as a safety net in reducing stress and improve the quality of life in university students amid the social crisis of the COVID-19 pandemic. In this regard, it is required to develop various programs for communication with parents, including parent-child communication techniques.