Objective: This study examines the prevalence of osteoporosis, and compares with activity of daily living(ADL), instrumental activity of daily living(IADL) and health-related quality of life(QoL) among the elderly people with disabilities. Methods: This study analyzed the data of 3,113 persons with disabilities over 65 years of age who responded to the questionnaire using data from the National Survey of People with Disabilities in 2017 on the people with disabilities (PWD). Descriptive statistics, X2-test, and independent sample t-test were conducted using the SPSS win 21.0 program. Results: The prevalence of osteoporosis in the elderly PWD was 18.7%. There were significant differences in sex, age, type of disability, and disability severity according to the presence or absence of osteoporosis (p<0.05). Walking and Transfer of ADL were related to osteoporosis in elderly PWD. Financial management and Transportation use of IADL were related to osteoporosis (p<0.05). The PWD with osteoporosis were analyzed to have lower health-related quality of life compared to the disabled elderly without osteoporosis (p<0.05).