Objectives: The study by analyzing the effects of social withdrawal of adolescents from multicultural families on the relationship between self-esteem and school adjustment, this study aims to find theorical and practical measures to increase school adjustment of adolescent from multicultural familes. Methods: This study utilized the 6th year data of the MAPS conducted by the National Youth Policy Institute. The data used in the analysis were self-esteem, social withdrawal, and school adjustment scale of adolescents from multicultural families. Results: First, the self-esteem of adolescents from multicultural families has a significant positive(+) effect on school adjustment. Second, the self-esteem of adolescents from multicultural families has a significant negative(-) effect on social withdrawal. Third, the social withdrawal of adolescents from multicultural families has a significant negative(-) effect on school adjustment. Fourth, significant influence to have an effect on school adjustment as mediation to be social withdrawal of self-esteem of adolescents from multicultural families. Conclusions: This study is meaningful in that it examined the school adjustment of adolescents from multicultural families in various aspects, such as individual psychological and emotional factors such as self-esteem and environmental factors such as social withdrawal.