Objects: The purpose of this study was to examine the differences of college students’ big-five personality factors, academic adaptation, and psychological well-being according to cluster types based on the grit. Methods: The participants of this study were 190 college students. All variables were evaluated by self-report of college students. The data were analyzed by one-way ANOVA and two-step clustering statistics using SPSS 21.0. Results: First, a cluster analysis on a sample of 190 college students revealed four clusters: the more highly grit group, higher tenacity group, higher consistency of interests, and the less grit group. Second, there were significant differences of 190 college students’ big five personality factors, academic adaptation, and psychological well-being according to cluster types based on the grit. Conclusions: These findings can be used as an important contribution to further research and educational practices for promoting the grit in college students. Also it suggests the need for health education to increase the psychological well-being of college students.